The Multiple Roles of EG-VEGF/PROK1 in Normal and Pathological Placental Angiogenesis
Identifieur interne : 000012 ( France/Analysis ); précédent : 000011; suivant : 000013The Multiple Roles of EG-VEGF/PROK1 in Normal and Pathological Placental Angiogenesis
Auteurs : Nadia Alfaidy [France] ; Pascale Hoffmann [France] ; Houssine Boufettal [Maroc] ; Naima Samouh [Maroc] ; Touria Aboussaouira [Maroc] ; Mohamed Benharouga [France] ; Jean-Jacques Feige [France] ; Sophie Brouillet [France]Source :
- BioMed Research International [ 2314-6133 ] ; 2014.
Abstract
Placentation is associated with several steps of vascular adaptations throughout pregnancy. These vascular changes occur both on the maternal and fetal sides, consisting of maternal uterine spiral arteries remodeling and placental vasculogenesis and angiogenesis, respectively. Placental angiogenesis is a pivotal process for efficient fetomaternal exchanges and placental development. This process is finely controlled throughout pregnancy, and it involves ubiquitous and pregnancy-specific angiogenic factors. In the last decade, endocrine gland derived vascular endothelial growth factor (EG-VEGF), also called prokineticin 1 (PROK1), has emerged as specific placental angiogenic factor that controls many aspects of normal and pathological placental angiogenesis such as recurrent pregnancy loss (RPL), gestational trophoblastic diseases (GTD), fetal growth restriction (FGR), and preeclampsia (PE). This review recapitulates EG-VEGF mediated-angiogenesis within the placenta and at the fetomaternal interface and proposes that its deregulation might contribute to the pathogenesis of several placental diseases including FGR and PE. More importantly this paper argues for EG-VEGF clinical relevance as a potential biomarker of the onset of pregnancy pathologies and discusses its potential usefulness for future therapeutic directions.
Url:
DOI: 10.1155/2014/451906
PubMed: 24955357
PubMed Central: 4052057
Affiliations:
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de la Santé et de la Recherche Médicale U1036 (INSERM U1036), Biologie du Cancer et de l'Infection, Laboratoire BCI-iRTSV, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale U1036 (INSERM U1036), Biologie du Cancer et de l'Infection, Laboratoire BCI-iRTSV, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Hoffmann, Pascale" sort="Hoffmann, Pascale" uniqKey="Hoffmann P" first="Pascale" last="Hoffmann">Pascale Hoffmann</name><affiliation wicri:level="3"><nlm:aff id="I1">Commissariat à l'Energie Atomique (CEA), DSV-iRTSV, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France</nlm:aff><country 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Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Boufettal, Houssine" sort="Boufettal, Houssine" uniqKey="Boufettal H" first="Houssine" last="Boufettal">Houssine Boufettal</name><affiliation wicri:level="1"><nlm:aff id="I5">Service de Gynécologie-Obstétrique “C”, Centre Hospitalier Universitaire Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Ain Chok, 1 rue des Hôpitaux-ex Banaflous, 20360 Casablanca, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Service de Gynécologie-Obstétrique “C”, Centre Hospitalier Universitaire Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Ain Chok, 1 rue des Hôpitaux-ex Banaflous, 20360 Casablanca</wicri:regionArea><wicri:noRegion>20360 Casablanca</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I6">Plateau Commun de Recherche, Unité de Culture Cellulaire, Faculté de Médecine et de Pharmacie, 19 rue Tarek Bnou Ziad, 20360 Casablanca, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Plateau Commun de Recherche, Unité de Culture Cellulaire, Faculté de Médecine et de Pharmacie, 19 rue Tarek Bnou Ziad, 20360 Casablanca</wicri:regionArea><wicri:noRegion>20360 Casablanca</wicri:noRegion></affiliation></author><author><name sortKey="Samouh, Naima" sort="Samouh, Naima" uniqKey="Samouh N" first="Naima" last="Samouh">Naima Samouh</name><affiliation wicri:level="1"><nlm:aff id="I5">Service de Gynécologie-Obstétrique “C”, Centre Hospitalier Universitaire Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Ain Chok, 1 rue des Hôpitaux-ex Banaflous, 20360 Casablanca, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Service de Gynécologie-Obstétrique “C”, Centre Hospitalier Universitaire Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Ain Chok, 1 rue des Hôpitaux-ex Banaflous, 20360 Casablanca</wicri:regionArea><wicri:noRegion>20360 Casablanca</wicri:noRegion></affiliation></author><author><name sortKey="Aboussaouira, Touria" sort="Aboussaouira, Touria" uniqKey="Aboussaouira T" first="Touria" last="Aboussaouira">Touria Aboussaouira</name><affiliation wicri:level="1"><nlm:aff id="I6">Plateau Commun de Recherche, Unité de Culture Cellulaire, Faculté de Médecine et de Pharmacie, 19 rue Tarek Bnou Ziad, 20360 Casablanca, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Plateau Commun de Recherche, Unité de Culture Cellulaire, Faculté de Médecine et de Pharmacie, 19 rue Tarek Bnou Ziad, 20360 Casablanca</wicri:regionArea><wicri:noRegion>20360 Casablanca</wicri:noRegion></affiliation></author><author><name sortKey="Benharouga, Mohamed" sort="Benharouga, Mohamed" uniqKey="Benharouga M" first="Mohamed" last="Benharouga">Mohamed Benharouga</name><affiliation wicri:level="3"><nlm:aff id="I1">Commissariat à l'Energie Atomique (CEA), DSV-iRTSV, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'Energie Atomique (CEA), DSV-iRTSV, 17 rue des Martyrs, 38054 Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="I2">Université Grenoble-Alpes, 38041 Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Grenoble-Alpes, 38041 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Grenoble-Alpes</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="I7">Centre National de la Recherche Scientifique, UMR 5249, 38054 Grenoble Cedex 9, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique, UMR 5249, 38054 Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Feige, Jean Jacques" sort="Feige, Jean Jacques" uniqKey="Feige J" first="Jean-Jacques" last="Feige">Jean-Jacques Feige</name><affiliation wicri:level="3"><nlm:aff id="I1">Commissariat à l'Energie Atomique (CEA), DSV-iRTSV, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'Energie Atomique (CEA), DSV-iRTSV, 17 rue des Martyrs, 38054 Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="I2">Université Grenoble-Alpes, 38041 Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Grenoble-Alpes, 38041 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Grenoble-Alpes</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="I3">Institut National de la Santé et de la Recherche Médicale U1036 (INSERM U1036), Biologie du Cancer et de l'Infection, Laboratoire BCI-iRTSV, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale U1036 (INSERM U1036), Biologie du Cancer et de l'Infection, Laboratoire BCI-iRTSV, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Brouillet, Sophie" sort="Brouillet, Sophie" uniqKey="Brouillet S" first="Sophie" last="Brouillet">Sophie Brouillet</name><affiliation wicri:level="3"><nlm:aff id="I1">Commissariat à l'Energie Atomique (CEA), DSV-iRTSV, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l'Energie Atomique (CEA), DSV-iRTSV, 17 rue des Martyrs, 38054 Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="I2">Université Grenoble-Alpes, 38041 Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Grenoble-Alpes, 38041 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Grenoble-Alpes</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="I3">Institut National de la Santé et de la Recherche Médicale U1036 (INSERM U1036), Biologie du Cancer et de l'Infection, Laboratoire BCI-iRTSV, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale U1036 (INSERM U1036), Biologie du Cancer et de l'Infection, Laboratoire BCI-iRTSV, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I4">CHU de Grenoble, Hôpital Couple Enfant, Département de Génétique et Procréation, Centre d'Aide Médicale à la Procréation, CS 10217, 38043 Grenoble Cedex 9, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU de Grenoble, Hôpital Couple Enfant, Département de Génétique et Procréation, Centre d'Aide Médicale à la Procréation, CS 10217, 38043 Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Placentation is associated with several steps of vascular adaptations throughout pregnancy. These vascular changes occur both on the maternal and fetal sides, consisting of maternal uterine spiral arteries remodeling and placental vasculogenesis and angiogenesis, respectively. Placental angiogenesis is a pivotal process for efficient fetomaternal exchanges and placental development. This process is finely controlled throughout pregnancy, and it involves ubiquitous and pregnancy-specific angiogenic factors. In the last decade, endocrine gland derived vascular endothelial growth factor (EG-VEGF), also called prokineticin 1 (PROK1), has emerged as specific placental angiogenic factor that controls many aspects of normal and pathological placental angiogenesis such as recurrent pregnancy loss (RPL), gestational trophoblastic diseases (GTD), fetal growth restriction (FGR), and preeclampsia (PE). This review recapitulates EG-VEGF mediated-angiogenesis within the placenta and at the fetomaternal interface and proposes that its deregulation might contribute to the pathogenesis of several placental diseases including FGR and PE. More importantly this paper argues for EG-VEGF clinical relevance as a potential biomarker of the onset of pregnancy pathologies and discusses its potential usefulness for future therapeutic directions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Burton, Gj" uniqKey="Burton G">GJ Burton</name></author><author><name sortKey="Jauniaux, E" uniqKey="Jauniaux E">E Jauniaux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackson, Mr" uniqKey="Jackson M">MR Jackson</name></author><author><name sortKey="Mayhew, Tm" uniqKey="Mayhew T">TM Mayhew</name></author><author><name sortKey="Boyd, Pa" uniqKey="Boyd P">PA Boyd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charnock Jones, Ds" uniqKey="Charnock Jones D">DS Charnock-Jones</name></author><author><name sortKey="Kaufmann, P" uniqKey="Kaufmann P">P Kaufmann</name></author><author><name sortKey="Mayhew, Tm" 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Kingdom</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Maroc</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement><orgName><li>Université Grenoble-Alpes</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Alfaidy, Nadia" sort="Alfaidy, Nadia" uniqKey="Alfaidy N" first="Nadia" last="Alfaidy">Nadia Alfaidy</name></region><name sortKey="Alfaidy, Nadia" sort="Alfaidy, Nadia" uniqKey="Alfaidy N" first="Nadia" last="Alfaidy">Nadia Alfaidy</name><name sortKey="Alfaidy, Nadia" sort="Alfaidy, Nadia" uniqKey="Alfaidy N" first="Nadia" last="Alfaidy">Nadia Alfaidy</name><name sortKey="Benharouga, Mohamed" sort="Benharouga, Mohamed" uniqKey="Benharouga M" first="Mohamed" last="Benharouga">Mohamed Benharouga</name><name sortKey="Benharouga, Mohamed" sort="Benharouga, Mohamed" uniqKey="Benharouga M" first="Mohamed" last="Benharouga">Mohamed Benharouga</name><name sortKey="Benharouga, Mohamed" sort="Benharouga, Mohamed" uniqKey="Benharouga M" first="Mohamed" last="Benharouga">Mohamed Benharouga</name><name sortKey="Brouillet, Sophie" sort="Brouillet, Sophie" uniqKey="Brouillet S" first="Sophie" last="Brouillet">Sophie Brouillet</name><name sortKey="Brouillet, Sophie" sort="Brouillet, Sophie" uniqKey="Brouillet S" first="Sophie" last="Brouillet">Sophie Brouillet</name><name sortKey="Brouillet, Sophie" sort="Brouillet, Sophie" uniqKey="Brouillet S" first="Sophie" last="Brouillet">Sophie Brouillet</name><name sortKey="Brouillet, Sophie" sort="Brouillet, Sophie" uniqKey="Brouillet S" first="Sophie" last="Brouillet">Sophie Brouillet</name><name sortKey="Feige, Jean Jacques" sort="Feige, Jean Jacques" uniqKey="Feige J" first="Jean-Jacques" last="Feige">Jean-Jacques Feige</name><name sortKey="Feige, Jean Jacques" sort="Feige, Jean Jacques" uniqKey="Feige J" first="Jean-Jacques" last="Feige">Jean-Jacques Feige</name><name sortKey="Feige, Jean Jacques" sort="Feige, Jean Jacques" uniqKey="Feige J" first="Jean-Jacques" last="Feige">Jean-Jacques Feige</name><name sortKey="Hoffmann, Pascale" sort="Hoffmann, Pascale" uniqKey="Hoffmann P" first="Pascale" last="Hoffmann">Pascale Hoffmann</name><name sortKey="Hoffmann, Pascale" sort="Hoffmann, Pascale" uniqKey="Hoffmann P" first="Pascale" last="Hoffmann">Pascale Hoffmann</name><name sortKey="Hoffmann, Pascale" sort="Hoffmann, Pascale" uniqKey="Hoffmann P" first="Pascale" last="Hoffmann">Pascale Hoffmann</name><name sortKey="Hoffmann, Pascale" sort="Hoffmann, Pascale" uniqKey="Hoffmann P" first="Pascale" last="Hoffmann">Pascale Hoffmann</name></country><country name="Maroc"><noRegion><name sortKey="Boufettal, Houssine" sort="Boufettal, Houssine" uniqKey="Boufettal H" first="Houssine" last="Boufettal">Houssine Boufettal</name></noRegion><name sortKey="Aboussaouira, Touria" sort="Aboussaouira, Touria" uniqKey="Aboussaouira T" first="Touria" last="Aboussaouira">Touria Aboussaouira</name><name sortKey="Boufettal, Houssine" sort="Boufettal, Houssine" uniqKey="Boufettal H" first="Houssine" last="Boufettal">Houssine Boufettal</name><name sortKey="Samouh, Naima" sort="Samouh, Naima" uniqKey="Samouh N" first="Naima" last="Samouh">Naima Samouh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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